December 5, 2025LifeOpen Access

Lyophilized Cell-Free Supernatants of Lacticaseibacillus paracasei T0901 Isolated from Fermented Palm Sap Exhibit Antiacne and Antimelanogenic Activities in B16F10 Melanoma Cells

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Inhibition against acne-associated bacteria was observed, significantly affecting microbial growth and biofilm formation.
Measured inhibition zones demonstrated strong antimicrobial activity, particularly against S. epidermidis and S. aureus.
Whole-genome sequencing identified relevant genes connected to antimicrobial and antimelanogenic properties, enhancing the bioactivity understanding.
Molecular docking indicated strong binding of metabolites to tyrosinase, highlighting potential for skin health applications.

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Exploratory analysis on antimicrobial activity and reduced melanin in melanoma cells suggests probiotic uses for acne vulgaris.

Sornsenee et al. (2025) studied this question.

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