Longitudinal analysis reveals DNA methylation predicts lung function and inflammation in cystic fibrosis patients, indicating potential clinical markers.
We provide the first longitudinal assessment of genome-wide DNA methylation in a cohort of patient with CF and identify CpG sites that predict clinical traits of key importance for lung disease. The associated genes play a critical role in inflammation or pancreatic endocrine activity. Overall, our results underscore the emerging role of DNA methylation as a key modulator of disease severity in CF.
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Tost et al. (2025) studied this question.
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