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Acute Myeloid Leukemia With KMT2A Rearrangement Presenting as Skin Hyperpigmentation

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Case report reveals acute myeloid leukemia with skin hyperpigmentation and lymphadenopathy, suggesting a rare prognosis.

Skin hyperpigmentation was identified as an atypical sign of acute myeloid leukemia, highlighting the need for awareness.
A skin biopsy revealed myeloperoxidase-positive immature leukocytes and a diagnosis of leukemia cutis.
The patient's diagnosis included an 11q23 KMT2A rearrangement, a mutation correlated with poor prognosis.
Recognizing cutaneous manifestations can improve outcomes in patients with acute myeloid leukemia and leukemia cutis.

O'Reilly et al. (2025) studied this question.

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