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December 5, 2025Hospital Practice

The efficacy of melatonin as a preoperative anxiolytic in real-world setting: a randomized controlled trial

Omar Ismail Karam Albdour Kamel Jaber Y. Jaber Amin Alsaras Ahmad Younis Ubadah Froukh Yazan Momani Sami A. Abu‐Halaweh

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Key Points

Melatonin reduces anxiety in preoperative settings, enhancing patient comfort before surgery.
In a randomized controlled trial, participants receiving melatonin experienced decreased anxiety levels compared to the control group.
The trial assessed the effects of melatonin on anxiety in a real-world clinical setting.
Findings suggest that melatonin could offer a non-pharmaceutical option for managing preoperative anxiety.

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Implication

Randomized controlled trial shows melatonin reduces anxiety in preoperative patients, suggesting it may improve surgical experiences.

Abstract

Nct06103188.

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Cite This Study

Ismail et al. (2025) studied this question.

synapsesocial.com/papers/694022612d562116f28fc8be https://doi.org/10.1080/21548331.2025.2600245

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials with Trial Sequential AnalysisMeta-Analysis · 2026
2Role of oral melatonin in prevention of postoperative delirium in patients undergoing elective surgery under general anesthesia: A Randomized controlled trial2024 · 6 citations
3Anxiolytic and Sedative Properties of Melatonin Premedication in Pediatrics Undergoing Elective Cardiac Catheterization: A Randomized Placebo Study2024 · 4 citations
4Preoperative 15 mg of melatonin for reducing anxiety and post-traumatic stress disorder symptoms in mandibular third molar surgery: A randomized double-blind placebo-controlled clinical trialHuman Clinical Trial · 2020
5Perioperative Administration of Oral Melatonin for Hemodynamic and Analgesic Control during Dental Implant Placement: A Clinical Study2025

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