December 5, 2025Nano LIFE

Spliceosome-Directed Antisense Nanocomplexes for Aberrant Transcript-Selective Gene Repression: A Concise Review

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Gene repression via spliceosome-directed delivery is a promising strategy for aberrant splicing conditions.
Antisense oligonucleotides showed improved efficacy when combined with lipid nanoparticles and dendrimers.
Assessment of delivery mechanisms highlights reducing off-target effects and immunogenicity in therapeutic applications.
Enhancing cellular uptake is critical for translating antisense therapies into clinical practice.

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Implication

Review demonstrates enhanced delivery of antisense oligonucleotides using nanocarriers, suggesting promising RNA therapies for glioblastoma and spinal muscular atrophy.

Cite This Study

Nitin Tandon (2025) studied this question.

synapsesocial.com/papers/694022612d562116f28fc8dc https://doi.org/10.1142/s1793984426300037

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Implication

Review demonstrates enhanced delivery of antisense oligonucleotides using nanocarriers, suggesting promising RNA therapies for glioblastoma and spinal muscular atrophy.

Spliceosome-Directed Antisense Nanocomplexes for Aberrant Transcript-Selective Gene Repression: A Concise Review

Key Points

Discussion

Implication

Cite This Study

Spliceosome-Directed Antisense Nanocomplexes for Aberrant Transcript-Selective Gene Repression: A Concise Review

Key Points

Discussion

Implication

Cite This Study

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