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December 4, 2025BMC NeurologyOpen Access

Restless legs syndrome as a comorbidity in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Fereshteh Farajdokht

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Key Points

Restless legs syndrome is notably prevalent in amyotrophic lateral sclerosis patients, impacting their health.
Meta-analysis shows restless legs syndrome significantly worsens quality of life and mental health.
Systematic review across multiple studies highlights the correlation between restful sleep and overall patient well-being.
Recognizing restless legs syndrome in ALS patients may facilitate better management strategies for improving life quality.

Implication

Systematic review reveals restless legs syndrome worsens sleep and quality of life in ALS patients, suggesting a need for clinician awareness.

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Cite This Study

Fereshteh Farajdokht (2025) studied this question.

synapsesocial.com/papers/694023fa2d562116f28fdb66 https://doi.org/10.1186/s12883-025-04543-4

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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