Observational study reveals high restless legs syndrome frequency without elevated periodic limb movements in multiple sclerosis, suggesting a distinct symptomatic disease mechanism.
RLS is highly frequent in patients with MS. The frequency of PLMS is comparable to the general population. The low percentage of patients with RLS having a high PLMSI, together with the absence of correlation between RLS and female gender and older age, supports the existence of a distinct symptomatic form of RLS in MS.
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Sparasci et al. (2021) studied this question.
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