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Controlled experiments showcase enhanced reactivity under specific reaction conditions, indicating improved catalyst efficiency in domino reactions.
Herein, we present an efficient synthesis of diverse dibenzo[b,d]azepines in high yields via Pd-catalyzed domino reactions of 2,2'-dihalobiphenyls with N-allyl alkylamines. The key to this success is in situ generation of a five-membered, chelated Pd(IV) species via the subsequent activation of two C-Br bonds at the initial step, supported by control experiments, density functional theory, and machine learning calculations.
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Fan et al. (2025) studied this question.
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