Pd(II)-Catalyzed Domino Aminopalladation/Desymmetrizative Ring-Opening of Diazabicycles: Synthesis of Indolyl-Functionalized Cyclopentenylamines

Haoyuan Lin; Junjie Meng; Yue Zhang; Zhaodong Li

doi:10.1039/d6cc00349d

January 1, 2026Chemical Communications

Pd(II)-Catalyzed Domino Aminopalladation/Desymmetrizative Ring-Opening of Diazabicycles: Synthesis of Indolyl-Functionalized Cyclopentenylamines

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Key Points

The aim is to develop a new synthetic method using Pd(II) to produce indolyl-functionalized cyclopentenylamines.
Utilized Pd(II) catalysis for a domino ring-opening reaction.
Coupled diazabicyclic alkenes with 2-alkynylanilines.
Sought to create a library of functionalized compounds.
Achieved efficient synthesis of a variety of indolyl-functionalized cyclopentenylamines.
Demonstrated the versatility of the method for generating complex structures.
Results indicate a robust coupling strategy with high yields.

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Implication

This research reveals a Pd(II)-catalyzed method to synthesize indolyl-functionalized compounds, suggesting new routes in organic chemistry.

Abstract

We report herein a robust Pd(II)-catalyzed domino ring-opening coupling of diazabicyclic alkenes with 2-alkynylanilines, enabling efficient access to a diverse library of densely functionalized indolated cyclopentenylamines. This methodology provides a...

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Lin et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f105a333a821460de00 https://doi.org/10.1039/d6cc00349d

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Pd(II)-Catalyzed Domino Aminopalladation/Desymmetrizative Ring-Opening of Diazabicycles: Synthesis of Indolyl-Functionalized Cyclopentenylamines

Key Points

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Implication

Abstract

Discussion

Cite This Study

Pd(II)-Catalyzed Domino Aminopalladation/Desymmetrizative Ring-Opening of Diazabicycles: Synthesis of Indolyl-Functionalized Cyclopentenylamines

Key Points

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Implication

Abstract

Discussion

Cite This Study

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