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December 3, 2025Organic Letters

Visible-Light-Induced Defluorinative Giese Reaction of gem -Difluorides via the ConPET Process: A Route to tert -Alkyl Fluorides

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Authors

XHXin HongZYZi-Hang YuanSWShutao Wang

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Overview

Metal-free defluorinative Giese reaction improves synthesis of tert-alkyl fluorides from gem-difluorides, suggesting advanced chemical methods for polyfluorinated compounds.

Key Points

  • Defluorinative Giese reaction yields tert-alkyl fluorides from gem-difluorides under mild conditions.
  • The process utilizes photoinduced electron transfer and hydrogen atom transfer for radical formation.
  • Synthesis method shows excellent functional group compatibility and high atom efficiency.
  • Highlights the potential of metal-free methods to enhance chemical synthesis involving polyfluorinated compounds.

Cite This Study

Hong et al. (2025) studied this question.

synapsesocial.com/papers/694025842d562116f28fe66ahttps://doi.org/10.1021/acs.orglett.5c04689
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