(E)-8-(4-(4-(Diphenylamino)styryl)phenoxy)-N,N,N-trimethyloctan-1-aminium Bromide

Structural optimization integrating triphenylamine and quaternary ammonium salt-based antimicrobial peptide mimics has yielded novel theranostic hybrid molecules. These compounds exhibit fluorescence imaging, photodynamic antibacterial activity, and membrane-disruption capabilities, demonstrating broad-spectrum efficacy with low resistance induction. In this study, we successfully developed a novel triphenylamine-quaternary ammonium derivative (TPQ), ultimately obtaining the target compound (E)-8-(4-(4-(diphenylamino)styryl)phenoxy)-N,N,N-trimethyloctan-1-aminium bromide (Compound 5). This achievement provides a potent strategy against growing bacterial drug resistance.