Adolescent “Lean PCOS” Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile

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Analysis reveals greater insulin resistance in adolescents with polycystic ovary syndrome, suggesting metabolic challenges despite normal weight.

Adolescents with lean PCOS show higher insulin resistance compared to those without, highlighting metabolic challenges in this group.
Participants with polycystic ovary syndrome displayed increased insulin resistance, with metrics indicating significant hormonal imbalances.
Using linear regression, we analyzed cardiometabolic biomarkers to understand how polycystic ovary syndrome affects growth and adiposity.
This evidence underscores the importance of monitoring metabolic health in adolescents with polycystic ovary syndrome, regardless of weight.

Whooten et al. (2025) studied this question.

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Analysis reveals greater insulin resistance in adolescents with polycystic ovary syndrome, suggesting metabolic challenges despite normal weight.