1-[4-(4-Chlorophenyl)piperazin-1-yl]-2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethan-1-one

Heterocyclic systems such as 1,2,4-triazoles and piperazines play an important role in modern medicinal chemistry due to their structural diversity and broad spectrum of biological activities. In this Short Note, we report the synthesis and spectroscopic characterization of a new hybrid molecule combining both pharmacophoric fragments: 1-[4-(4-chlorophenyl)piperazin-1-yl]-2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethan-1-one (compound 3). The compound was obtained in 70% yield via S-alkylation of 4-phenyl-1,2,4-triazole-3-thione with a chloroacetyl derivative of 4-chlorophenylpiperazine under alkaline conditions. The structure of 3 was confirmed by 1H and 13C NMR spectroscopy, DEPT-135, 2D NMR (COSY, NOESY, HSQC, HMBC), FT-IR, and elemental analysis. These results support the utility of combining triazole and piperazine fragments in the design of new heterocyclic frameworks with potential biological relevance.