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Analysis reveals limited utility of adaptive sampling for metagenomic samples, suggesting pore loss issues hinder ONT sequencing.
We conclude that the utility of NAS is often limited by the characteristics of the metagenomic sample studied, and that the factors contributing to pore loss need to be resolved before ONT sequencing can be reliably applied to long-read metagenomics.
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Top et al. (2025) studied this question.
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