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December 1, 2025Journal of Cachexia Sarcopenia and MuscleOpen Access

Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway

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Authors

MZMengxue ZhangLCLi-Li ChenRWRuichang Wang

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Overview

Observational analysis showed that decorin deficiency exacerbates muscle fibrosis in aging mice, indicating ITGB1 signaling involvement.

Key Points

  • Gastrocnemius muscle exhibited increased fibrosis in decorin-deficient mice, reducing grip strength by 21.7%.
  • Significant upregulation of fibronectin and α-SMA was noted in D-Galactose-treated decorin-deficient cells.
  • Co-immunoprecipitation revealed decorin's interaction with ITGB1, crucial for Akt/mTOR pathway modulation.
  • Findings highlight decorin as a potential therapeutic target in age-related sarcopenia despite preclinical model limits.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69402a652d562116f2901b36https://doi.org/10.1002/jcsm.70144
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