Au (I)/Ag (I)‐Catalyzed Regio‐ and Stereoselective Synthesis of 5‐Alkylidene‐Pyrrolidin‐2‐ones From Linear Alkynoic Acids and Amines

Herein, we report the regio‐ and stereoselective synthesis of 5‐alkylidene‐pyrrolidin‐2‐one derivatives through an Ag (I) or Au (I)‐catalyzed cascade reaction between linear alkynoic acids and primary amines. This protocol features excellent regio‐ and stereoselectivity, good functional group tolerance, broad substrate scope, good to high yields, and high bond‐forming efficiency, thus providing an efficient and convenient route to a variety of 5‐alkylidene‐pyrrolidin‐2‐ones.