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December 1, 2025ChemistrySelectOpen Access

In Silico and In Vitro Antimicrobial Evaluation of Iron(III) and Nickel(II) Schiff Base Complexes Bearing a Hydroxyethyl‐Substituted Ligand

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Authors

MBMohammed A.O. BasubaihHEHany M. Abd El‐LateefMKMai M. Khalaf

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Overview

Antimicrobial activity improved by metal complexes in vitro, indicating potential against drug-resistant pathogens.

Key Points

  • Metal complexes showed enhanced antimicrobial activity, with E. coli displayed increased inhibition from 40% to 88%.
  • Characterization involved techniques like mass spectrometry and infrared spectroscopy to confirm stable complex formation.
  • Molecular docking studies revealed strong ligand–protein interactions, supporting antimicrobial findings against E. coli.
  • Highlights the potential of metal complexes as candidates in the fight against drug-resistant pathogens.

Cite This Study

Basubaih et al. (2025) studied this question.

synapsesocial.com/papers/69402a722d562116f2901ef3https://doi.org/10.1002/slct.202505075
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