December 1, 2025JACC. Clinical electrophysiology0 citationsOpen Access

Ultra-Low Temperature Cryoablation Combined With Pulsed Field Ablation in a Swine Ventricular Infarct Model

TDThomas A. Dewland RVRamkumar Venkateswaran SHSatoshi Higuchi

Key Points

Ablation resulted in substantial lesions in both healthy and infarcted myocardium, improving treatment efficacy.
The addition of pulsed field ablation (PFA) allowed for larger lesions compared to ablation alone.
Assessment using a swine ventricular infarct model demonstrated successful outcomes with combination techniques.
Combination of techniques may enhance therapeutic outcomes, but further studies are needed for clinical application.

Abstract

ULTC resulted in clinically substantial lesions in healthy and infarcted ventricular myocardium. The addition of PFA to ULTC allowed for larger and more transmural lesions compared with a single ULTC ablation alone while avoiding the longer ablation times associated with 2 successive freezes.

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Cite This Study

Dewland et al. (Mon,) studied this question.

synapsesocial.com/papers/69402a722d562116f2901fa0 https://doi.org/https://doi.org/10.1016/j.jacep.2025.09.017

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