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December 1, 2025eLightOpen Access

Research highlight: new and powerful approach to wide-field fluorescence lifetime imaging with single-molecule sensitivity

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Authors

JEJörg Enderlein

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Overview

Novel multimodal imaging method achieves single-molecule sensitivity in fluorescence lifetime imaging, suggesting enhanced biological analysis.

Key Points

  • Single-molecule sensitivity was achieved by employing a novel multimodal imaging technique, enhancing quantitative assays.
  • The new method utilizes a single-photon camera for high-throughput fluorescence lifetime imaging, improving efficiency.
  • Observational analysis revealed applications for nanoscale location and environments of biological molecules in living systems.
  • This advancement supports broader applications in biophysical parameter mapping, indicating potential impacts on biological research.

Cite This Study

Jörg Enderlein (2025) studied this question.

synapsesocial.com/papers/69402a7e2d562116f2902206https://doi.org/10.1186/s43593-025-00117-6
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  1. 1Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera2025
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  5. 5Fast volumetric fluorescence lifetime imaging of multicellular systems using single-objective light-sheet microscopy2025 · 6 citations