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December 1, 2025Frontiers in Aging NeuroscienceOpen Access

How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings

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Authors

APAntonietta PepeAAAsieh Amousoltani AraniFBFrancesca Bracone

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Overview

Narrative review shows obesity affects cognitive impairment and dementia in adults and elderly, pointing to neuroimaging findings.

Key Points

  • Cognitive impairment and dementia are linked to obesity, with the brain showing notable changes due to adiposity.
  • Obesity can lead to decreased neuroimaging measures, suggesting significant impacts on brain structure and function.
  • Narrative review of neuroimaging and neurocognitive literature reveals effects of obesity on neurological health.
  • Potential neurodegeneration in elderly highlights the need for specific interventions in this age group.

Cite This Study

Pepe et al. (2025) studied this question.

synapsesocial.com/papers/69402c4d2d562116f2902a39https://doi.org/10.3389/fnagi.2025.1616303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OBESITY AS A FACTOR AFFECTING COGNITIVE FUNCTIONS: NEUROBIOLOGICAL AND METABOLIC MECHANISMS – A REVIEW OF CURRENT EVIDENCE2026
  2. 2Neurometabolic and Neuroinflammatory Consequences of Obesity: Insights into Brain Vulnerability and Imaging-Based Biomarkers2026 · 9 citations
  3. 3Body–Brain Connections: The Effects of Obesity and Behavioral Interventions on Neurocognitive Aging2017 · 65 citations
  4. 4The obesity-brain axis: a comprehensive review of neurological complications and therapeutic interventions in metabolic syndrome2026 · 1 citations
  5. 5Abstract P327: Examination of Cardiometabolic Health Status, Obesity, and Brain Health in Community-Dwelling Older Adults2024