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November 28, 2025Neurological Research

Melatonin regulates the MST1/Nrf2 pathway to alleviate oxidative stress injury after hypoxic-ischemic brain damage in neonatal rats

Yuexia Zhang Wen‐Liang Gao Wei Shang Xiaoli Wang Shuna Yu

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Abstract

Melatonin protects against HIBD by reducing oxidative stress via MST1 inhibition and subsequent Nrf2/HO-1 pathway activation. The MST1-Nrf2 axis is a key mechanism, offering new insights and a potential therapeutic target for neonatal HIE.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69402e042d562116f29046fb https://doi.org/10.1080/01616412.2025.2591278

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