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The research aims to explore how melatonin impacts neurovascular unit dysfunction in neonatal rats suffering from hypoxic-ischemic brain damage.

January 14, 2026Neurological Research0 citations

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Melatonin attenuates neurovascular unit dysfunction via AKT/GSK-3β/CREB pathway in hypoxic-ischemic neonatal rats

CLChenmeng Liu MYMiao Yu YWYijing Wang

Key Points

The research aims to explore how melatonin impacts neurovascular unit dysfunction in neonatal rats suffering from hypoxic-ischemic brain damage.
Used multiparametric MRI to assess brain microstructure and blood-brain barrier (BBB) integrity.
Administered melatonin to neonatal rats with hypoxic-ischemic brain damage (HIBD).
Analyzed the activation of the AKT/GSK-3β/CREB signaling pathway.
Melatonin administration improved neurovascular unit integrity in neonatal rats with HIBD.
Changes in brain microstructure and BBB permeability were effectively monitored via MRI.
AKT/GSK-3β/CREB pathway activation was confirmed as a mechanism of action for melatonin.

Abstract

Multiparametric MRI techniques can monitor the changes of brain microstructure and BBB permeability in neonatal rats with HIBD in vivo at early stage. Mel administration can reduce the NVU injury in neonatal rats with HIBD via activating AKT/GSK-3β/CREB pathway.

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Melatonin attenuates neurovascular unit dysfunction via AKT/GSK-3β/CREB pathway in hypoxic-ischemic neonatal rats

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