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November 28, 2025Radiotherapy and OncologyOpen Access

Quality of life and late toxicity after total neoadjuvant treatment for locally advanced rectal cancer – LARCT-US

Tanweera Khan Per J. Nilsson

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Abstract

An abbreviated TNT schedule, compared with the RAPIDO-study, used in LARCT-US, achieves favourable oncological outcomes with low risk of late toxicity, and an acceptable QoL similar to other less effective neoadjuvant treatments.

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Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/69402fd52d562116f2904e11 https://doi.org/10.1016/j.radonc.2025.111318

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Locoregional and systemic control following total neoadjuvant therapy with short-course radiotherapy for locally advanced rectal cancer: long-term outcomes from the LARCT-US studyRandomized Controlled Trial · 2026 · 4 citations
2Reconsidering functional outcomes in watch-and-wait rectal cancer after total neoadjuvant treatmentRandomized Controlled Trial · 2026 · 1 citations
3Locoregional control following TNT using short-course radiotherapy in rectal cancer: long-term results from the Swedish LARCT-US study2025
4Total Neoadjuvant Therapy With Long-Course Radiotherapy Versus Chemoradiotherapy in High-Risk Locally Advanced Rectal Cancer (TNTCRT): A Multicenter, Randomized, Phase III TrialLate-Phase Clinical Trial · 2026
5Implementing RAPIDO Protocol for Total Neoadjuvant Treatment of Carcinoma Rectum: A Real Life Experience from a Tertiary Care Cancer Center in India.Feasibility Study · 2026 · 1 citations

More related papers

Total neoadjuvant treatment in locally advanced rectal cancer: A retrospective multicentre cohort analysis in three cancer centres in Brazil.2026
Low-intensity induction chemotherapy before chemoradiotherapy for rectal cancer: 10-year overall survival in the LARC-RRP trial2026
Functional Outcomes and Quality of Life in Patients Managed With Organ Preservation Following Total Neoadjuvant Therapy for Rectal Cancer—A Historical Cohort Study2025

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