Reconsidering functional outcomes in watch-and-wait rectal cancer after total neoadjuvant treatment

We read with great interest the paper by Israa Imam et al. [1] 1. Imam, I. ∙ Khan, T. ∙ Nilsson, P.J. ... Quality of life and late toxicity after total neoadjuvant treatment for locally advanced rectal cancer - LARCT-US Radiother Oncol. 2026; 214 , 111318 Google Scholar entitled Quality of Life and Late Toxicity After Total Neoadjuvant Treatment for Locally Advanced Rectal Cancer (LARCT-US). This study evaluated quality of life and late toxicity in patients with locally advanced rectal cancer who received a reduced total neoadjuvant treatment regimen. The results showed that this simplified TNT approach achieved favorable oncologic outcomes, a low risk of late toxicity, and acceptable quality of life comparable to that reported in the RAPIDO trial with fewer chemotherapy cycles.