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November 26, 2025Science Translational Medicine

An early clinical trial of 5-ALA sonodynamic therapy in recurrent high-grade glioma

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Authors

NSNader SanaiATArtak TovmasyanATAn-Chi Tien

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Sanai et al. (2025) studied this question.

synapsesocial.com/papers/694035f62d562116f2909358https://doi.org/10.1126/scitranslmed.ads5813
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An early clinical trial of 5-ALA sonodynamic therapy in recurrent high-grade glioma2025 · 18 citations
  2. 2P12.28.A A CLINICAL UPDATE OF A FIRST-IN-HUMAN PHASE 0/1 TRIAL OF 5-AMINOLEVULINIC ACID SONODYNAMIC THERAPY (5-ALA SDT) IN RECURRENT GLIOBLASTOMA.2025
  3. 3EXTH-55. Targeting Malignant Gliomas with 5-ALA Sonodynamic Therapy: In Vitro Efficacy, HIFU-Delivered In Vivo Treatment, and Berberine Potentiation2025
  4. 4P07.20.B SONODYNAMIC THERAPY WITH A SINGLE NEOADJUVANT, DIFFUSE DELIVERY OF LOW-INTENSITY ULTRASOUND WITH 5-ALA IN TREATMENT NAÏVE GLIOBLASTOMA RESULTS IN TUMOR-SPECIFIC CYTOTOXIC EDEMA AND INCREASED APOPTOSIS2025
  5. 5181 Initial Experience With Sonodynamic Therapy Using Low-Intensity Focused Ultrasound and ALA for Pediatric Patients With Diffuse Intrinsic Pontine Glioma2024