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November 1, 2025Neuro-OncologyOpen Access

EXTH-55. Targeting Malignant Gliomas with 5-ALA Sonodynamic Therapy: In Vitro Efficacy, HIFU-Delivered In Vivo Treatment, and Berberine Potentiation

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Authors

SSSatoshi SuehiroYOYoshihiro OhtsukaDYDaisuke Yamashita

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Overview

In vitro findings show sonodynamic therapy improves tumor growth and apoptosis in gliomas, suggesting berberine enhances treatment efficacy.

Key Points

  • This study aims to evaluate the efficacy of sonodynamic therapy combining 5-ALA and berberine on malignant gliomas.
  • Evaluated cytotoxic effects of 5-ALA-sonodynamic therapy on glioma cells in vitro.
  • Analyzed apoptosis and reactive oxygen species levels in treated cells.
  • Studied tumor growth and survival effects in mice subjected to 5-ALA-sonodynamic therapy with high-intensity focused ultrasound.
  • Assessed berberine's impact on 5-ALA-induced fluorescence using flow cytometry.
  • 5-ALA-sonodynamic therapy induced apoptosis and inhibited cell growth in glioma cells.
  • The therapy increased reactive oxygen species levels, which were essential for its cytotoxic effects.
  • In vivo treatment significantly prolonged survival in tumor-bearing mice with observed tumor necrosis and apoptosis.
  • Berberine enhanced 5-ALA-induced fluorescence, especially in glioma stem-like cells.

Cite This Study

Suehiro et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc358595https://doi.org/10.1093/neuonc/noaf201.1388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An early clinical trial of 5-ALA sonodynamic therapy in recurrent high-grade glioma2025 · 17 citations
  2. 2An early clinical trial of 5-ALA sonodynamic therapy in recurrent high-grade glioma2025
  3. 3P07.20.B SONODYNAMIC THERAPY WITH A SINGLE NEOADJUVANT, DIFFUSE DELIVERY OF LOW-INTENSITY ULTRASOUND WITH 5-ALA IN TREATMENT NAÏVE GLIOBLASTOMA RESULTS IN TUMOR-SPECIFIC CYTOTOXIC EDEMA AND INCREASED APOPTOSIS2025
  4. 4P12.28.A A CLINICAL UPDATE OF A FIRST-IN-HUMAN PHASE 0/1 TRIAL OF 5-AMINOLEVULINIC ACID SONODYNAMIC THERAPY (5-ALA SDT) IN RECURRENT GLIOBLASTOMA.2025
  5. 5EXTH-39. Inhibition of glioma cell invasiveness by sonodynamic therapy2025