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February 8, 2026Cancer Biotherapy and Radiopharmaceuticals

Sonodynamic Therapy: Porphyrin-Based Sensitizers and Low-Intensity Ultrasound for Precision Treatment of Glioblastoma

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Authors

HAHuda M. AlshanbariMAMohammed E. AbakerYAYazeed AlashbanKing Saud Medical City

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Implication

Preclinical research demonstrates enhanced apoptosis in glioblastoma cells using porphyrin sensitizers and ultrasound, suggesting a promising therapeutic strategy.

Key Points

  • The study aims to evaluate the effectiveness of porphyrin-based sensitizers combined with low-intensity ultrasound in inducing cell death in glioblastoma cells.
  • Tested three porphyrin sensitizers (P1, P2, P3) with U87-MG glioblastoma cell cultures.
  • Applied low-intensity pulsed ultrasound (1 MHz, 1.0 W/cm²) to enhance treatment.
  • Measured reactive oxygen species production and apoptosis rates under various treatments.
  • Performed multivariate regression analysis to assess interaction effects.
  • Combination of P3 and LIPUS increased ROS production 3.2 times compared to control.
  • Apoptosis rates reached 46.7% with combined treatment versus 8.6% in untreated cells.
  • Statistical significance was noted for the interaction between sensitizer concentration and ultrasound exposure.
  • P3 exhibited the highest synergy index, indicating enhanced effects.

Cite This Study

Alshanbari et al. (2026) studied this question.

synapsesocial.com/papers/6988291e0fc35cd7a8849287https://doi.org/10.1177/10849785261418890
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