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November 25, 2025BMC UrologyOpen Access

Effect of GLP-1 agonists on testosterone levels: a systematic review and meta-analysis

Susan Orra Juan Victor Nabhan Martinez Breno Cordeiro Porto Carlo C. Passerotti

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Abstract

GLP-1 RAs appear to elevate bioavailable testosterone and improve glycemic control, while effects on free testosterone and SHBG remain inconclusive. These findings suggest possible endocrine benefits of GLP-1 therapy; however, further well-powered studies are warranted.

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Orra et al. (2025) studied this question.

synapsesocial.com/papers/694035fb2d562116f2909848 https://doi.org/10.1186/s12894-025-02005-0

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