Key result
Advanced obstructive HCM links to widespread multi-compartment proteoform alterations versus nonfailing controls.
Case-Control
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Global top-down proteomics reveals extensive proteoform alterations beyond the sarcomere in advanced obstructive HCM, highlighting novel pathophysiological mechanisms and potential therapeutic targets.
Gao et al. (2025) conducted a case-control in Advanced obstructive hypertrophic cardiomyopathy. Advanced obstructive hypertrophic cardiomyopathy vs. Nonfailing controls was evaluated on Proteoform alterations across cellular compartments. Advanced obstructive hypertrophic cardiomyopathy was associated with significant alterations in sarcomeric, cytoskeletal, mitochondrial, and nucleosome proteoforms compared with nonfailing controls.
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