Key result
Advanced obstructive HCM is linked to widespread alterations across ~2,000 cellular proteoforms.
Case-Control
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Global top-down proteomics reveals significant proteoform alterations beyond the sarcomere in advanced obstructive HCM, highlighting potential novel pathophysiological mechanisms and therapeutic targets.
Gao et al. (2025) conducted a case-control in Obstructive Hypertrophic Cardiomyopathy. Advanced obstructive hypertrophic cardiomyopathy vs. Nonfailing controls was evaluated on Global proteoform alterations. Advanced obstructive hypertrophic cardiomyopathy was associated with significant alterations among ≈2000 detected proteoforms across multiple cellular compartments compared with nonfailing controls.
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