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November 24, 2025Proceedings of the National Academy of SciencesOpen Access

Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G

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ASAlexandra SchindlUniversity of LeedsMJMegan JonesLGLeela GhimireJohn Innes Centre

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Schindl et al. (2025) studied this question.

synapsesocial.com/papers/69403b952d562116f290c550https://doi.org/10.1073/pnas.2508779122
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of fusidic acid resistance2025
  2. 2Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis2024
  3. 3Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid2010 · 62 citations
  4. 4Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane2024 · 17 citations
  5. 5Structures of the <i>Staphylococcus aureus</i> ribosome inhibited by fusidic acid and fusidic acid cyclopentane2023