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November 20, 2023Open Access

Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane

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Why the study?

Fusidic acid is effective only against gram-positive bacteria, but available structures of fusidic acid-inhibited complexes were from gram-negative model organisms.

Population

Staphylococcus aureus ribosome in complex with mRNA, tRNA, and EF-G

Comparison

Fusidic acid vs fusidic acid-cyclopentane

Design

Cryo-EM structural study

Authors

AGAdrián González-LópezDLDaniel S. D. LarssonRKRavi Kiran Koripella

Discussion

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Overview

May inform next-gen antibiotic design vs resistant S. aureus; leaves open clinical translation.

Structured PICO

P
Population
Staphylococcus aureus ribosome in complex with mRNA, tRNA, and elongation factor G (EF-G)
I
Intervention
Fusidic acid (FA) and fusidic acid cyclopentane (FA-CP)
O
Outcome
Cryo-EM structures of the S. aureus ribosome complexessurrogate

High-resolution cryo-EM structures of the S. aureus ribosome inhibited by fusidic acid and its derivative reveal binding details that explain improved resistance profiles and provide a basis for structure-based drug discovery.

Cite This Study

González-López et al. (2023) studied this question.

synapsesocial.com/papers/6a7d3753ff1a536db837d351https://doi.org/10.1101/2023.11.17.567578
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane2024 · 17 citations
  2. 2Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid2010 · 62 citations
  3. 3Structural characterization of ribosome recycling and fusidic acid inhibition in <i>Staphylococcus aureus</i>2026
  4. 4Mechanisms of fusidic acid resistance2025
  5. 5Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G2025