Key result
Fusidic acid predominantly inhibits bacterial ribosome recycling by trapping elongation factor G on the post-termination complex in the absence of ribosome recycling factor.
Why the study?
Fusidic acid inhibits elongation and ribosome recycling by locking EF-G to the ribosome, but no functional ribosome recycling fusidic acid complex had been successfully captured.
Population
Staphylococcus aureus ribosomes
Design
Single-particle cryo-electron microscopy study
Authors
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Structural insights into fusidic acid should not yet change practice; leaves open translation to improved staphylococcal therapies.
The study provides structural insights into the molecular mechanism of bacterial ribosome recycling and the mode of action of fusidic acid.
González-López et al. (2026) studied Bacterial ribosome recycling. Fusidic acid was evaluated on Structural characterization of FA-stalled intermediates of Staphylococcus aureus ribosomes. Fusidic acid predominantly inhibits bacterial ribosome recycling by trapping elongation factor G on the post-termination complex in the absence of ribosome recycling factor.
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