November 24, 2025Biomedical and Biotechnology Research Journal (BBRJ)Open Access

Expression of Ki-67 and p53 in Triple-negative Breast Cancer: A Clinicopathological Study

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High Ki-67 expression independently predicts high-grade histology and nodal metastasis in triple-negative breast cancer, whereas p53 lacks independent prognostic value.
Ki-67 yielded an odds ratio of 6.75 for Grade III histology and 5.40 for lymph node metastasis, confirming a significant link with aggressive triple-negative breast cancer.
Prospective observational study evaluated 23 patients using immunohistochemistry, supporting routine Ki-67 testing while noting limited single-marker utility for p53.

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Implication

Prospective observational study demonstrates independent prognostic value of high Ki-67 expression in triple-negative breast cancer, highlighting its utility for routine pathological evaluation.

Cite This Study

Verma et al. (2025) studied this question.

synapsesocial.com/papers/69403b9b2d562116f290ca21 https://doi.org/10.4103/bbrj.bbrj_242_25

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Implication

Prospective observational study demonstrates independent prognostic value of high Ki-67 expression in triple-negative breast cancer, highlighting its utility for routine pathological evaluation.

Expression of Ki-67 and p53 in Triple-negative Breast Cancer: A Clinicopathological Study

Key Points

Discussion

Implication

Cite This Study

Expression of Ki-67 and p53 in Triple-negative Breast Cancer: A Clinicopathological Study

Key Points

Discussion

Implication

Cite This Study

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Also Consider