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The objective is to evaluate the prognostic significance of aminotransferase elevation in dengue patients.

December 14, 2025Apollo MedicineOpen Access

Aminotransferase Elevation as an Independent Predictor of Severity and Mortality in Dengue Fever: A Prospective Cohort Study from Western India

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The objective is to evaluate the prognostic significance of aminotransferase elevation in dengue patients.
Conducted a prospective observational study on 250 confirmed dengue patients at a tertiary-care hospital
Excluded patients with pre-existing liver disease, viral hepatitis, or hepatotoxic drug exposure
Analyzed clinical and biochemical parameters following WHO dengue classification
92% of patients showed elevated aspartate aminotransferase and 87.6% had elevated alanine aminotransferase levels
Severe hepatic enzyme elevation was associated with dengue haemorrhagic fever and increased mortality
Marked elevation of aminotransferases was linked to prolonged hospital stays and worsening thrombocytopenia

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Prospective cohort study finds elevated liver enzymes may indicate severity and mortality in dengue fever patients.

Krishnan et al. (2025) studied this question.

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