Investigation of hypoglycemic effects of Morus alba leaves extract in an animal model

The objective of the present investigation was to evaluate the therapeutic efficacy of Morus alba leaves in an animal model of diabetes. Animals were treated with Morus alba leaf extract 400 mg and 600 mg/kg body weight for 35 days. Blood glucose, glycosylated hemoglobin, triglyceride, LDL, VLDL, HDL, blood urea, cholesterol, number of β cells, and diameter of the islets of Langerhans were measured at the beginning and at the end of the experiment. Blood glucose level and other parameters (except HDL) were elevated in the diabetic group, but were brought to control group level in the diabetic group treated with 600 mg/kg body weight of Morus alba leaf extract. The diameter of the islets and the number of β cells were reduced in the diabetic group; both parameters were brought to control group level after treatment with Morus alba leaf extract. Morus alba leaf extract, at a dose of 600 mg/kg body weight, has therapeutic effects in diabetes-induced swiss albino mouse and can restore the diminished β cell numbers.