What question did this study set out to answer?

To evaluate the nephroprotective potential of Morus alba Linn leaf extract against streptozotocin-induced diabetic nephropathy.

May 19, 2025Phytomedicine PlusOpen Access

Protective effects of Morus alba Linn leaf extract on streptozotocin-induced diabetic nephropathy in mice model

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Authors

TPThanh Phuong QTQuang Vinh Trịnh NDNghia Trong Duong

Discussion

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Overview

Preclinical study demonstrates Morus alba leaf extract improves renal function and lowers blood glucose in diabetic mice, suggesting therapeutic promise for diabetic nephropathy.

Key Points

To evaluate the nephroprotective potential of Morus alba Linn leaf extract against streptozotocin-induced diabetic nephropathy.
Diabetic nephropathy was induced in Swiss mice using multiple low-dose intraperitoneal injections of streptozotocin.
Mice received oral Morus alba leaf extract at 820.8 mg/kg or 2462.4 mg/kg, or dapagliflozin (1 mg/kg) daily for 28 days.
Fasting blood glucose decreased from 16.56 ± 3.90 mmol/L in diabetic controls to 9.69 ± 2.15 mmol/L with low-dose extract (p < 0.01) and 12.51 ± 4.17 mmol/L with high-dose extract (p < 0.05).
Creatinine clearance rose from 16.80 ± 10.80 µl/min in diabetic controls to 41.84 ± 27.02 µl/min at low dose (p < 0.05) and 39.72 ± 15.54 µl/min at high dose (p < 0.01), alongside reduced glomerulosclerosis and tubular damage.
Treatment produced no significant improvements in oral glucose tolerance, malondialdehyde, or tumor necrosis factor-α levels.

Cite This Study

Phuong et al. (2025) studied this question.

synapsesocial.com/papers/6a7efe22088720e7049b29bd https://doi.org/10.1016/j.phyplu.2025.100819

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May 19, 2025Phytomedicine PlusOpen Access

Protective effects of Morus alba Linn leaf extract on streptozotocin-induced diabetic nephropathy in mice model

View Full Paper

Ask AI

Bookmark

Authors

TPThanh Phuong QTQuang Vinh Trịnh NDNghia Trong Duong

Discussion

Member takes

Overview

Preclinical study demonstrates Morus alba leaf extract improves renal function and lowers blood glucose in diabetic mice, suggesting therapeutic promise for diabetic nephropathy.

Key Points

To evaluate the nephroprotective potential of Morus alba Linn leaf extract against streptozotocin-induced diabetic nephropathy.
Diabetic nephropathy was induced in Swiss mice using multiple low-dose intraperitoneal injections of streptozotocin.
Mice received oral Morus alba leaf extract at 820.8 mg/kg or 2462.4 mg/kg, or dapagliflozin (1 mg/kg) daily for 28 days.
Fasting blood glucose decreased from 16.56 ± 3.90 mmol/L in diabetic controls to 9.69 ± 2.15 mmol/L with low-dose extract (p < 0.01) and 12.51 ± 4.17 mmol/L with high-dose extract (p < 0.05).
Creatinine clearance rose from 16.80 ± 10.80 µl/min in diabetic controls to 41.84 ± 27.02 µl/min at low dose (p < 0.05) and 39.72 ± 15.54 µl/min at high dose (p < 0.01), alongside reduced glomerulosclerosis and tubular damage.
Treatment produced no significant improvements in oral glucose tolerance, malondialdehyde, or tumor necrosis factor-α levels.

Cite This Study

Phuong et al. (2025) studied this question.

synapsesocial.com/papers/6a7efe22088720e7049b29bd https://doi.org/10.1016/j.phyplu.2025.100819

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