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December 19, 2025Human MutationOpen Access

Stem Cell–Related Gene CALR as a Novel Prognostic Factor for Bladder Cancer: Implications for Immunotherapy

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Authors

ZLZhihao LingSHS. HeTLTianyu Li

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Overview

Investigation identifies CALR as a prognostic marker linked to tumor recurrence in bladder cancer, highlighting its implications for immunotherapy.

Key Points

  • This research aims to evaluate the role of CALR in bladder cancer prognosis and response to immunotherapy.
  • Utilized cluster analysis to assess relationships between stem cell-related genes and prognostic outcomes in bladder cancer.
  • Employed the XGBoost algorithm to identify CALR as a significant prognostic marker.
  • Investigated immune cell infiltration and CALR's interaction with mitomycin using molecular docking methods.
  • Conducted in vitro experiments to validate the impact of CALR on bladder cancer stem cells.
  • Applied various machine learning techniques to highlight essential stem cell-associated genes.
  • CALR was identified as a notable prognostic marker in bladder cancer linked to patient outcomes.
  • Strong correlation found between CALR expression and prognostic outcomes in bladder cancer.
  • Reduction of CALR expression resulted in diminished stemness features in bladder cancer cells.
  • Study underscores the significance of stem cell-related genes for bladder cancer diagnosis and therapeutic strategies.

Cite This Study

Ling et al. (2025) studied this question.

synapsesocial.com/papers/69449a992f0218eca95088fdhttps://doi.org/10.1155/humu/5569005
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