Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 30, 2025GenesOpen Access

Integrative Analysis of Biomarkers for Cancer Stem Cells in Bladder Cancer and Their Therapeutic Potential

View Full Paper
Ask AI
Bookmark
Share

Authors

JWJing WuWLWei Liu

Discussion

Loading...

Member takes

Overview

Observational analysis reveals an 8-gene prognostic signature in bladder cancer, suggesting targeted therapies may improve outcomes.

Key Points

  • The 8-gene prognostic signature significantly predicts overall survival in bladder cancer patients, enhancing treatment personalization.
  • An analysis of 665 cancer stem cell genes identified 120 with significant differential expression, leading to a robust predictive model.
  • This integrative approach combined clinical data with functional analyses, utilizing Cox regression and LASSO for model development.
  • Findings indicate drug sensitivities vary among patient groups, highlighting the potential for personalized therapeutic strategies.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68dc26218a7d58c25ebb2ea8https://doi.org/10.3390/genes16101146
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the stem cell landscape and identification of a stemness-associated prognostic signature in bladder cancer2024
  2. 2Development and verification of cell cycle-related gene markers for prognosis in bladder cancer2026
  3. 3A novel prognostic model based on CD8+T cell infiltration-associated differentially expressed genes and immune-related genes predicts survival in bladder cancer2026
  4. 4Construction and evaluation of a bladder cancer prognosis model based on super-enhancer-associated genes2026
  5. 5A bladder cancer–associated gene signature for exploratory qPCR-based survival stratification in NAC-Treated muscle-invasive bladder cancer2026