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July 23, 2026Journal of Translational MedicineOpen Access

A bladder cancer–associated gene signature for exploratory qPCR-based survival stratification in NAC-Treated muscle-invasive bladder cancer

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Authors

XCX N ChenTSToru SakataniSTSunao Tanaka

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Overview

Randomized trial demonstrates survival stratification utility in NAC-treated muscle-invasive bladder cancer, indicating potential therapeutic pathways.

Key Points

  • To define a ten-gene signature that predicts prognosis and therapeutic response in muscle-invasive bladder cancer.
  • Integrated bulk transcriptomic data from TCGA with snRNASeq of primary MIBC tumors.
  • Applied machine-learning to qPCR data for exploratory survival stratification.
  • Built an expression-based BLCA signature score to assess its association with clinical outcomes.
  • Expression-based BLCA signature score correlated with worse overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI).
  • The model achieved a C-index of 0.695 after optimism correction, indicating moderate discrimination for survival prediction.
  • High-signature tumors exhibited immune dysregulation with increased checkpoint expression and reduced antigen presentation.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a61b02ffaa9903c5116ad45https://doi.org/10.1186/s12967-026-08681-2
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