Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 25, 2026Discover OncologyOpen Access

Construction and evaluation of a bladder cancer prognosis model based on super-enhancer-associated genes

View Full Paper
Ask AI
Bookmark
Share

Authors

LXLieyu XuZZZhenhao ZengXZXinchang Zou

Discussion

Loading...

Member takes

Overview

Evaluation of a prognosis model reveals super-enhancer-associated genes impact outcomes in bladder cancer, suggesting new treatment insights.

Key Points

  • The aim is to construct and evaluate a prognosis model for bladder cancer using super-enhancer-associated genes.
  • Used TCGA-BLCA and GSE31684 for data analysis.
  • Conducted differential expression analysis to identify DEGs.
  • Applied univariate Cox and Lasso regression to build the risk model.
  • Performed survival analysis using Kaplan-Meier curves and ROC curves for validation.
  • Analyzed immune cell proportions using CIBERSORT algorithm.
  • Identified 70 differential super-enhancer-associated genes (DE-SERGs).
  • Constructed a prognosis model based on MXRA7, PLEKHG4B, and ATP2B4.
  • Model demonstrated strong predictive ability for BLCA outcomes as indicated by ROC curves.
  • Risk score correlated positively with certain immune cells, while negatively with others.
  • Identified top drugs like AZD8186 and JQ1 for potential bladder cancer treatment.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69c37b11b34aaaeb1a67d2ffhttps://doi.org/10.1007/s12672-026-04851-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancing bladder cancer management: development of a prognostic model and personalized therapy2024 · 7 citations
  2. 2A novel prognostic model based on CD8+T cell infiltration-associated differentially expressed genes and immune-related genes predicts survival in bladder cancer2026
  3. 3Development of a prognostic model related to mitochondria and programmed cell death-related genes in bladder cancer2025
  4. 4Risk Score Model of Aging-Related Genes for Bladder Cancer and Its Application in Clinical Prognosis2025
  5. 5Integrative Analysis of Biomarkers for Cancer Stem Cells in Bladder Cancer and Their Therapeutic Potential2025