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May 22, 2026Cancer BiomarkersOpen Access

Development and verification of cell cycle-related gene markers for prognosis in bladder cancer

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Authors

HLHui LiDZD Zhu

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Overview

Randomized trial identifies gene markers that predict survival outcomes in bladder cancer, suggesting personalized therapy possibilities.

Key Points

  • This research aims to identify cell cycle-related gene markers that can predict prognosis in bladder cancer.
  • Analyzed transcriptomic profiles from TCGA to find significant gene expression differences between early- and advanced-stage bladder cancer.
  • Developed a prognostic model using nine key genes selected via LASSO regression.
  • Conducted functional enrichment analyses and immune cell infiltration studies to evaluate the biological relevance of the gene signature.
  • High-risk patients exhibited significantly worse overall survival compared to low-risk patients (exact survival rates not specified).
  • Receiver operating characteristic (ROC) curve analyses supported the prognostic value of the gene signature.
  • Functional analyses demonstrated associations with critical processes like proliferation and increased M2 macrophage infiltration in high-risk tumors.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3aed674f7c03778c83ehttps://doi.org/10.1177/18758592261449024
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Also Consider

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  1. 1Identification and validation of basement membrane-related genes predicting prognosis and immune infiltration associated with bladder cancer2024 · 3 citations
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  3. 3A novel prognostic model based on CD8+T cell infiltration-associated differentially expressed genes and immune-related genes predicts survival in bladder cancer2026
  4. 4Integrative Analysis of Biomarkers for Cancer Stem Cells in Bladder Cancer and Their Therapeutic Potential2025
  5. 5Integrative analysis of the bladder cancer from a cell cycle <scp>NCAM1</scp> perspective at both single cell and bulk resolution2024 · 3 citations