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July 19, 2024MedicineOpen Access

Identification and validation of basement membrane-related genes predicting prognosis and immune infiltration associated with bladder cancer

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Authors

FLFie LaiHLHe LinTLThongher Lia

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Overview

Bioinformatic analysis demonstrates poor overall survival and chemoresistance in bladder cancer patients, highlighting its value for risk stratification.

Key Points

  • A three-gene basement membrane signature accurately predicts poor overall survival in bladder cancer, stratifying individuals into distinct risk groups.
  • Patients in the high-risk group exhibited higher IC50 values for cisplatin and gemcitabine, alongside elevated M2 macrophages and resting mast cells.
  • Validation across independent genomic datasets and immunohistochemistry confirms that elevated EFEMP1, GPC2, and ITGA3 expression marks aggressive disease.

Cite This Study

Lai et al. (2024) studied this question.

synapsesocial.com/papers/68e5fb84b6db64358758fc31https://doi.org/10.1097/md.0000000000038858
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