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Findings reveal hinokitiol's anti-inflammatory effects and its potential to combat oxidative stress in tissue injury.
Background Ionizing radiation (IR) disrupts redox balance and causes tissue injury through reactive oxygen species. Although the Nrf2–ARE pathway governs antioxidant defense, effective radioprotective activators remain limited. Hinokitiol, a natural antioxidant and anti-inflammatory tropolone, has not been previously evaluated in vivo for Nrf2-mediated radioprotection.
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Fekry et al. (2025) studied this question.
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