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This study aims to explore the photoprotective effects of Samia ricini cocoon extract on human dermal fibroblast cells under UVB exposure.

Photoprotective Effect of Samia ricini (Drury, 1773) Silkworm Cocoon Extract on Viability and Collagen Production in Human Dermal Fibroblast (HDF) Cells Induced by UVB Irradiation

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This study aims to explore the photoprotective effects of Samia ricini cocoon extract on human dermal fibroblast cells under UVB exposure.
Human dermal fibroblast cells (HDF) were treated with Samia ricini cocoon extract (EKUS) after UVB irradiation.
Cell viability was measured using the MTT assay.
Collagen production was assessed through the Sirius Red assay.
HDF cells were exposed to varying concentrations of EKUS and UVB radiation.
Pre-treatment with 500 µg mL-1 EKUS maintained cell viability above 80% post-UVB exposure.
At 1000 µg mL-1, EKUS significantly enhanced cell viability to 123.86% and 128.39% at different cell densities.
EKUS at 900 µg mL-1 increased collagen production to 146.30% and 189.04% at respective concentrations.

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Findings show Samia ricini cocoon extract enhances collagen production in human dermal fibroblasts, suggesting it may protect cells from UVB damage.

Angelina et al. (2025) studied this question.

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Findings show Samia ricini cocoon extract enhances collagen production in human dermal fibroblasts, suggesting it may protect cells from UVB damage.