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December 20, 2025Open Access

Detecting EGFR Gene Mutations on a Nanobioarray Chip

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Authors

FXFang XuMBMontek BoparaiCOChristopher Oberc

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Overview

Point mutations in the EGFR gene impact lung cancer therapy, indicating gold nanoparticles enhance detection sensitivity.

Key Points

  • This research aims to detect specific point mutations in the EGFR gene related to lung cancer treatment.
  • Point mutations in EGFR were identified using a nanobioarray chip.
  • Probes were designed for detecting mutations in genomic samples through DNA hybridization.
  • Gold nanoparticles were used to enhance differentiation of sequences related to drug sensitivity.
  • Identified mutations include T790M (TKI-resistant) and L858R, L861Q (TKI-sensitive).
  • Gold nanoparticle-assisted method improved detection accuracy of mutated versus wild-type sequences.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/6945e9325151ab1219e4d60fhttps://doi.org/10.20944/preprints202512.1447.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detecting EGFR Gene Mutations on a Nanobioarray Chip2026
  2. 2Artificial intelligence-driven methods and nanoparticle-based biosensors for rapid and sensitive detection of EGFR mutations in non-small cell lung cancer2026
  3. 3Highly Sensitive 3D‐Nanoplasmonic‐Based Epidermal Growth Factor Receptor Mutation Multiplex Assay Chip for Liquid Biopsy2024
  4. 4Custom-Designed Probes for the Accurate Determination of Epidermal Growth Factor Receptor Mutations and Their Allelic Configuration2024
  5. 5A “turn-on” CRISPR-mediated method using enhanced fluorescent bimetallic DNA nanoclusters for EGFR mutation detection in non-small cell lung cancer2026