What question did this study set out to answer?

To analyze differences in radiographic spinal progression between axial spondyloarthritis and psoriatic arthritis with inflammatory axial involvement.

December 20, 2025Arthritis Research & TherapyOpen Access

Comparison of radiographic spinal changes and their progression in patients with axial spondyloarthritis vs. psoriatic arthritis with inflammatory axial involvement

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To analyze differences in radiographic spinal progression between axial spondyloarthritis and psoriatic arthritis with inflammatory axial involvement.
Retrospective cohort study of 246 patients with axSpA and PsA-ax
Participants underwent lateral radiographs of the cervical, thoracic, and/or lumbar spine
Radiographic progression measured using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS)
Adjusted linear mixed-effects model analyzed longitudinal mSASSS differences between groups
Baseline mSASSS was significantly higher in axSpA (6) compared to PsA-ax (0.96)
Mean mSASSS change over 2 years was greater in axSpA (0.39) versus PsA-ax (0.07)
27% of axSpA patients had mSASSS change >0 units compared to 5% in PsA-ax
Adjusted analysis suggested slightly lower mSASSS progression in PsA-ax, but with wide confidence interval

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Implication

Retrospective cohort reveals lower spinal progression in psoriatic arthritis than axial spondyloarthritis, suggesting clinical distinction.

Cite This Study

Sewerin et al. (2025) studied this question.

synapsesocial.com/papers/6945ea41742299010fff02ec https://doi.org/10.1186/s13075-025-03692-8

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Implication

Retrospective cohort reveals lower spinal progression in psoriatic arthritis than axial spondyloarthritis, suggesting clinical distinction.

Comparison of radiographic spinal changes and their progression in patients with axial spondyloarthritis vs. psoriatic arthritis with inflammatory axial involvement

Key Points

Discussion

Implication

Cite This Study

Comparison of radiographic spinal changes and their progression in patients with axial spondyloarthritis vs. psoriatic arthritis with inflammatory axial involvement

Key Points

Discussion

Implication

Cite This Study

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