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Isolation of antifungal compounds from Diaporthe spinosa shows potential against Bipolaris sorokiniana, suggesting new treatments.
A new monosubstituted phenol, Diaphenol A (1), along with nine related analogues, 2-phenylethanol (2), (4-methoxyphenyl)acetic acid (3), 3-hydroxybenzyl alcohol (4), 1-phenyl-1,2-ethanediol (5), bungein A (6), 2-(4-hydroxyphenyl)ethyl acetate (7), hydroxyphenylacetic acid (8), tyrosol (9), and orcinol (10) were isolated from the mangrove-derived fungus Diaporthe spinosa ZMU-32-1. The chemical structures of these compounds were elucidated through comprehensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionisation mass spectrometry (HR-ESIMS), and by comparison with previously reported spectral data. The antifungal activity of compounds 1–10 was evaluated, among which compound 6 exhibited notable antifungal activity against Bipolaris sorokiniana, with a minimum inhibitory concentration (MIC) value of 80 μg/mL.
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Li et al. (2025) studied this question.
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