One new polyketide, diaporone B, isolated from the endophytic fungus Diaporthe discoidispora MQZ-Z1 and its antifungal activity

One previously undescribed polyketide, diaporone B (1), along with four known polyketides (2–5), was isolated from the endophytic fungus Diaporthe discoidispora MQZ-Z1, which was derived from the leaves of Strychnos nux-vomica L. Their chemical structures were elucidated by HRESIMS, 1D and 2D NMR spectroscopy. Compounds 1–5 were evaluated for their fungistatic activity against Candida albicans CMCC 98001 and Aspergillus niger R330. Among them, compound 2 showed antifungal activity against C. albicans with an MIC value of 12.5 μg/mL.