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April 20, 2001Science

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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Authors

PJPanu JaakkolaTurku University HospitalDMDavid R. MoleAustralian National UniversityYTYa‐Min TianUniversity of Oxford

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Jaakkola et al. (2001) studied this question.

synapsesocial.com/papers/695d26f3fc1b1b644ea5cf4ehttps://doi.org/10.1126/science.1059796
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of hypoxia-inducible factor 1α is mediated by an O <sub>2</sub> -dependent degradation domain via the ubiquitin-proteasome pathway1998 · 2,119 citations
  2. 2Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α1998 · 629 citations
  3. 3Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analog N-oxaloglycine and its derivatives1992 · 94 citations
  4. 4Perspectives on Oxygen Sensing1999 · 395 citations
  5. 5HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing2001 · 4,758 citations